تأثیر تغذیة پیوگلیتازون بر تخمک‌ریزی و برخی بیماری‌های پس از زایش در گاوهای هولشتن

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری، پردیس کشاورزی و منابع طبیعی دانشگاه تهران، کرج

2 استادیار، پردیس کشاورزی و منابع طبیعی دانشگاه تهران، کرج

3 استاد، پردیس کشاورزی و منابع طبیعی دانشگاه تهران، کرج

4 استاد دانشکدة کشاورزی دانشگاه شیراز و قطب علمی بررسی مشکلات تولیدمثلی گاوهای شیری پرتولید، دانشگاه شیراز

چکیده

هدف این پژوهش بررسی اثر پیوگلیتازون بر کنش تخمدان و کاهش برخی بیماری‌های پس از زایش در گاوهای هولشتن بود. تعداد هشتاد گاو شیری هولشتن به‌صورت تصادفی در چهار گروه تیماری (20n=) با آرایش فاکتوریل 2×2 قرار گرفتند. تغذیة پیوگلیتازون از 14 روز مانده به زمان مورد انتظار زایش تا 21 روز پس از زایش انجام شد. تغذیة پیوگلیتازون پیش و پس از زایش، عامل اصلی در نظر گرفته شد؛ گاوها در هر دوره با یکی از دو سطح صفر یا 6 میلی‌گرم به ازای هر کیلوگرم وزن بدن پیوگلیتازون تغذیه شدند. فراسنجه‌های وابسته به سلامت گاو و روز تخمک‌ریزی رکوردبرداری و داده‌ها با نرم‌افزار SAS و رویه‌های GENMOD یاGLM  واکاوی شدند. تغذیة پیوگلیتازون در دورة پس از زایش، میانگین فاصلة زایش تا نخستین تخمک‌ریزی را کاهش داد (02/0P<). افزون بر این، شمار گاوهایی که در 14 روز نخست پس از زایش تخمک‌ریزی کردند نیز با تغذیة پیوگلیتازون در دورة پس از زایش افزایش یافت (03/0P<). تغذیة پیوگلیتازون در دوره‌های پیش از زایش (01/0P<) و پس از زایش (10/0P<) بسامد بروز لنگش را کاهش داد. پیوگلیتازون اثر معناداری بر بسامد ورم پستان نداشت. تغذیة پیوگلیتازون در دوره‌های پیش از زایش (03/0P<) و پس از زایش (08/0P<) درصد گاوهای دچار عفونت‌های رحم را کاهش داد. تغذیة پیوگلیتازون پس از زایش،کیست‌های تخمدانی را کاهش داد (04/0P<). درصد گاوهایی که تخمدان نافعال داشتند تحت تأثیر پیوگلیتازون قرار نگرفت. یافته‌ها نشان دادند که تغذیة پیوگلیتازون به گاوهای شیری دردورة انتقال می‌تواند سبب بهبود کنش‌های تخمدان شود و در عین حال برخی بیماری‌های پس از زایش را کاهش دهد.

کلیدواژه‌ها

عنوان مقاله [English]

Effects of pioglitazone on ovulation and selected postpartum diseases in Holstein cows

نویسندگان [English]

  • Ali Reza Yousefi 1
  • Hamid Kohram 2
  • Ahmad Zare Shahneh 3
  • Mohammad Javad Zamiri 4
  • Fateme Ghaziani 1
  • Ali Rezaei Roodbari 1
1 Ph.D. Student, University College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran
2 Assistant Professor, Professors and Ph. D. Students, University College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran.
3 Department of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran.
4 Professor, Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, and Center of Excellence for Studies on Reproductive Problems in High-Producing Dairy Cows, Shiraz University (MJZ).
چکیده [English]

The aim of the present study was to determine the effect of dietary supplementation of pioglitazone (PGT) during transition period on the ovarian function and the incidence of several diseases after parturition. Eighty Holstein cows were randomly allocatted to four treatment groups (n=20) using a 2×2 factorial design.  Pioglitazone was fed for 14 day before the expected parturition time, or for 21 days after parturition, or furing both pre- and post-partum period. The cows received either 0 or 6 mg PGT/kg live weight. Data on the incidence of production diseases (laminitis, mastitis, cystic ovaries, infected uterus and inactive ovaries) and the day of ovulation were recorded and analyzed using the GENMOD and GLM procedures of SAS. Postpartum supplementation of PGT decreased the mean days to ovulation (P<0.02). The percentage of cows which ovulated during 14 DIM was significantly increased when PGT was supplemented postpartum (P<0.03). PGT supplementation during prepartum (p<0.01) and postpartum (P<0.10) periods decreased laminitis. Prepartum PGT supplementation had no significant effect on mastitis incidence. Prepartum (P<0.03) and postpartum (P<0.08) PGT supplementation resulted in decreased uterine infections. Postpartum PGT supplementation significantly decreased the proportion of cystic cows (P<0.04). PGT had no significant effect on the percentage of cows with inactive ovaries (P>0.05). In conclusion, supplementation of PGT during transition period in dairy cows may be beneficial in decreasing the incidence of some postpartum diseases, and may enhance ovarian cyclicity after parturition.

کلیدواژه‌ها [English]

  • Dairy Cows
  • Ovarian function
  • Pioglitazone
  • postpartum diseases
  • Transition period

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سابقه مقاله

  • تاریخ دریافت: 09 اردیبهشت 1393
  • تاریخ بازنگری: 21 خرداد 1393
  • تاریخ پذیرش: 03 تیر 1393

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