نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه علوم دامی، دانشکده کشاورزی، دانشگاه شهیدباهنر کرمان، ایران.
2 بخش علوم دامی، دانشکده کشاورزی، دانشگاه شهید باهنر کرمان، کرمان. ایران
3 گروه علوم دامی، دانشکده کشاورزی، دانشگاه شهیدباهنرکرمان، ایران.
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Marbling, or intramuscular fat, is a critical quality trait in beef cattle, directly influencing flavor, juiciness, and tenderness, and significantly contributing to the economic value and marketability of beef. This meta-analysis aimed to identify genomic regions and gene networks associated with marbling in beef cattle. Utilizing data from genome-wide association studies (GWAS) and gene coexpression network analysis, we investigated genomic regions and candidate genes influencing this trait. Data were collected from reputable scientific databases, standardized, and analyzed using Fisher’s and Stouffer’s statistical methods to enhance statistical power. Results revealed that chromosome 15, harboring the CADM1 gene with the highest significance level (-log10(p) = 29.24), plays a pivotal role in regulating marbling. Chromosomes 1, 2, 12, 17, 19, and 24 were also identified as key regions containing genes related to lipid metabolism and immune response. Gene coexpression network analysis identified two hub genes, CLEC12A and CD69, on chromosome 5, which regulate biological pathways including lipid metabolism, immune regulation, cellular signaling, and transcriptional control. The scale-free network structure demonstrated biological stability and flexibility. These findings provide opportunities for developing molecular markers for targeted genomic selection, enhancing beef quality and increasing the global competitiveness of the beef industry. Future studies leveraging whole-genome sequencing and multi-omics analyses can further refine these results.
کلیدواژه‌ها [English]
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