Effect of nano folic acid and folic acid on mortality rate and homocysteine concentration in broiler chickens

Articles in Press

Document Type : Research Paper

Authors

1 Department of Animal Science, Faculty of Animal Science, Sari University of Agricultural Sciences and Natural Resources, Sari, Iran

2 Department of Animal Science, Faculty of Animal Science and Fisheries, Sari Agricultural Sciences and Natural Resources University, Sari, Iran.

3 Mycology and Medical Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran.

10.22059/ijas.2024.367860.653973

Abstract

The aim of this research was the effect of nano folic acid and folic acid supplementation in reducing serum homocysteine level and mortality rate in broiler chickens. A total of 250 male broiler chickens of Ras 308 breed were implemented for 42 days as a completely randomized design in a 2x2 factorial format with five treatments and five repetitions and ten chickens in each repetition. The treatments include: 1) control diet, 2) folic acid-free diet with folic acid supplement (4 mg per liter of water) in non-nano form, 3) folic acid-free diet with folic acid supplement (4 mg per liter of water) in nano form, 4 ) control diet with folic acid supplement (4 mg per liter of water) in non-nano form, 5) control diet with folic acid supplement (4 mg per liter of water) in nano form. The results showed that normal folic acid significantly decreased homocysteine concentration in serum and decreased mortality (P<0.05), but in nano folic acid treatment this decrease was more than other treatments. The interaction effect of nano folic acid and regular folic acid supplements significantly reduced serum homocysteine levels compared to the control (P<0.05), but the control treatment had the highest level of homocysteine concentration and the highest mortality. In addition, normal folic acid and nano folic acid significantly increased the concentration of thyroid hormones (T3 and T4) compared to the control treatment (P<0.05). Therefore, we conclude that nano folic acid is more effective than regular folic acid in reducing blood homocysteine concentration.

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Iranian Journal of animal Science

Articles in Press, Accepted Manuscript
Available Online from 03 December 2024

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History

  • Receive Date: 12 November 2023
  • Revise Date: 08 November 2024
  • Accept Date: 10 November 2024

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