The pattern of runs of homozygosity, heterozygosity and genomic inbreeding in the population of sensitive and resistant sheep to footrot

Articles in Press

Document Type : Research Paper

Authors

1 Department of Animal Science, Faculty of Animal Science and Fisheries, Sari Agricultural Sciences and Natural Resources University, Sari-Iran

2 Department of Animal Science, Faculty of Animal Science and Fisheries, Sari Agricultural Sciences and Natural Resources University, SARI-IRAN

Abstract

In this study, the genomic inbreeding coefficient based on runs of homozygosity (FROH) in the genomic regions of sheep sensitive and resistant to footrot was estimated. Swiss Alpine sheep data genotyped with Ovine SNP 600K BeadChip in a case-control study (154 healthy controls versus 76 severe cases) were used. FROH estimates ranged from 0.03 to 0.13, with a mean of 0.09. The highest FROH percentage was related to chromosome 2 (85.5%) and 1 (84.3%). The lowest FROH percentage was related to chromosome 8 (0.65%). 68959 runs of homozygosity (ROH) and 731026 runs of heterozygosity (ROHet) were detected in the healthy population and, 34569 ROH and 364125 ROHet in the case population. Using ROH, the highest percentage of observations of the healthy population was related to the 0-6 Mbp class (98.79%), and the lowest percentage of observations related to the class more than 48 Mbp (0.01%). The highest percentage of observations of the case population was related to Mbp 0-6 class (98.81%), and the lowest percentage of observations was related to 24-48 Mbp class. For ROHet, the highest percentage of observations of the healthy population was related to 0-6 Mbp class (99.99%), and the lowest percentage of observations was related to 6-12 Mbp class; for the case population, the lowest percentage was related to 6-12 Mbp and Mbp 24-48 classes. Totally, the healthy population had more number of homozygosity and heterozygosity pattern as well as the average length of heterozygosity pattern and a more ancient inbreeding than the case population.

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Iranian Journal of animal Science

Articles in Press, Accepted Manuscript
Available Online from 10 July 2024

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History

  • Receive Date: 24 February 2024
  • Revise Date: 13 June 2024
  • Accept Date: 15 June 2024

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