The effect of different levels of organic selenium on blood parameters of roosters ‎under dexamethasone stress

Document Type : Research Paper

Authors

1 M.Sc. Graduate, Department of Animal Science, College of Agriculture ‎and Natural Resources, University of Tehran, Karaj, Iran.‎

2 Professor, Department of Animal Science, College of Agriculture ‎and Natural Resources, University of Tehran, Karaj, Iran.‎

3 Professor, Department of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran‎

4 Associate Professor, Department of Animal Science, College of Agriculture and Natural Resources, ‎University of Tehran, Karaj, Iran‎

5 Assistant Professor, Department of Pathology and Experimental Animals, Razi Vaccine and Serum Research Institute, Agricultural ‎Research Education and Extension Organization (AREEO), Karaj, Iran

Abstract

The aim of the present study was to investigate the effect of dietary supplementation of organic selenium (oSe) on blood parameters of male broiler breeder under dexamethasone (Dexa) challange. Fifty broiler breeder roosters (Ross 308) at the age of 64 weeks were randomly allotted to five groups (10 roosters/group) and fed a standard diet supplemented with different levels of oSe during 10 successive weeks of the experimental period. To induce stress, dexamethasone (2 mg/kg body weight) was injected during weeks of 4 to 6 of the experiment, in one-day-interval manner. Experimental treatments including diet without oSe supplementation and Dexa treatments (negative control; NC), or treated with Dexa and different levels of oSe including 0 (positive control; PC), 0.15 (Se15+Dexa), 0.30 (Se30+Dexa) or 0.45 (Se45+Dexa) mg/kg of diet. During the experimental period, concentration of testosterone, corticosterone, malondialdehyde (MDA), total antioxidant capacity (TAC), hepatic enzymes activity (ALT and AST), uric acid, total protein, albumin, plasma lipid and glucose parameters, were evaluated every two weeks. Liver enzymes and glutathione peroxidase (GPX) activity, TAC, concentration of uric acid, total protein, albumin and glucose were not affected by the treatments. Dexamethasone injection increased plasma concentrations of total cholesterol, HDL, LDL and MDA in the PC group compared to the NC group (P<0.05). However, oSe ameliorated these negative impacts in dexamethasone-stressed roosters (P<0.05). Generally, the results of this study indicate that dietary inclusion of oSe mitigate the negative effects of Dexa on some blood parameters in roosters under dexamethasone challange.

Keywords

References

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Iranian Journal of animal Science
Volume 53, Issue 2
July 2022
Pages 69-79

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History

  • Receive Date: 11 July 2021
  • Revise Date: 07 December 2021
  • Accept Date: 07 December 2021

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