Effect of retinol acetate on immune system in male broiler breeder

Document Type : Research Paper

Authors

1 M. Sc. Student, University College of Agriculture & Natural Resources, University of Tehran, Karaj, Iran

2 Professor of Poultry Science, University College of Agriculture & Natural Resources, University of Tehran, Karaj, Iran

3 Associate Professor of Poultry Science, University College of Agriculture & Natural Resources, University of Tehran, Karaj, Iran

Abstract

The aim of this research was to determine effects of different levels of all-trans-retinol acetate on immunity performance of broiler breeder roosters and also to find the level with most immunity performance. * Treatments were consisted of 5 level all-trans-retinol acetate (0, 6000, 12000, 18000, 24000 IU/kg) added to basal diet. * 60 broiler breeder roosters were used from 45 to 48 weeks of their rearing period in a completely randomized design with 12 replicates per treatment. * Cell immune system response was measured by PHA-P sensitivity and blood immunity was measured by antibody titr against SRBC. * Titr of antibody against SRBC was affected by retinol acetate level (P<0.05) and blood immunity repose was increased by increasing level of retinol acetate. * Highest and lowest blood immune responses belong to 24000 and zero IU/kg treatments respectively (P≤0.03). * Increasing level of retinol acetate increased IgM (P≤0.04). * The results of cutaneous sensitively showed increasing effect of retinol acetate till 18000 IU/kg (P<0.05). * The results of this research showed that 18000 Iu/kg of retinol acetate resulted in best level of immune system in broiler breeder roosters, and this amount is higher than suggested amount by ROSS 308 catalogue.

Keywords

References

  1. Clagett-Dame, M. & DeLuca, H. F. (2002). The role of vitamin A in mammalian reproduction and embryonic development. Annual review of nutrition 22, 347-381.
  2. Corrier, D & DeLoach, J. (1990). Evaluation of cell-mediated, cutaneous basophil hypersensitivity in young chickens by an interdigital skin test. Poultry science 69, 403-408.
  3. Dawson, H. D., Li, N-Q., DeCicco, K. L., Nibert, J. A. & Ross, A. C. (1999). Chronic marginal vitamin A status reduces natural killer cell number and function in aging Lewis rats. The Journal of Nutrition,129, 1517-1510.
  4. García, O. P. (2012). Effect of vitamin A deficiency on the immune response in obesity. Proceedings of the Nutrition Society, 71, 290-297.
  5. Hosseini, S., Arshami, J. & Torshizi, M. (2010). Immunomodulatory effects of graded copper and zinc on SRBC titer and lymphoid organs in broiler chicks. Journal of Animal and Veterinary Advances, 9, 1650-1653.
  6. Isakov, N., Feldman, M. & Segal, S. (1982). The mechanism of modulation of humoral immune responses after infection of mice with lactic dehydrogenase virus. The Journal of Immunology, 128, 969-975.
  7. Kidd, M. (2005). Relationship between the nutritional requirements and the immune system in poultry. Simposio internacional sobre exigencies nutricionais de aves e suinos, 2, 29-31.
  8. Klasing, K. (2007). Nutrition and the immune system. British Poultry Science, 48, 525-537.
  9. Kozakova, H., Hanson, L. A., Stepankova, R., Kahu, H., Dahlgren, U. I. & Wiedermann, U. (2003). Vitamin A deficiency leads to severe functional disturbance of the intestinal epithelium enzymes associated with diarrhoea and increased bacterial translocation in gnotobiotic rats. Microbes and Infection, 5, 405-411.
  10. Lessard, M., Hutchings, D. & Cave, N. (1997). Cell-mediated and humoral immune responses in broiler chickens maintained on diets containing different levels of vitamin A. Poultry Science, 76, 1368-1378.
  11. Li, T. & Li, Y. (2007). Synergistic effect of zinc and vitamin A on T cell functions. Biomedical and Environmental Sciences, 20, 131.
  12. Maggini, S., Wintergerst, E. S., Beveridge, S. & Hornig, D. H. (2007). Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. British Journal of Nutrition, 98, S29-S35.
  13. Niu, Z., Wei, F., Liu, F., Qin, X., Min, Y. & Gao, Y. (2009). Dietary vitamin A can improve immune function in heat-stressed broilers. Animal, 3, 1442-1448.
  14. Owen, J. A., Punt, J. & Stranford, S. A. (2013). Kuby immunology. WH Freeman New York.
  15. Preedy, V. R., Watson, R. R. & Zibadi, S. (2010). Dietary Components and Immune Function. Humana.
  16. Reifen, R., Nur, T., Ghebermeskel, K., Zaiger, G., Urizky, R. & Pines, M. (2002). Vitamin A deficiency exacerbates inflammation in a rat model of colitis through activation of nuclear factor-κB and collagen formation. The Journal of Nutrition, 132, 2743-2747.
  17. Roch, G., Boulianne, M. & De Roth, L. (2000). Effect of dietary vitamin E and selenium on incidence of ascites, growth performance and blood parameters in cold-stressed broiler. Poultry Science, 41, 179.
  18. Sepehri Moghaddam, H. & Emadi, M. (2014). The effect of threonine and vitamin A on immune system in broiler chickens. International Journal of Advanced Biological and Biomedical Research, 2, 756-763.
  19. Stephensen, C. B. (2001). Vitamin A, infection, and immune function. Annual Review of Nutrition, 21, 167-192.
  20. Van den Berg, R., Haenen, G., Van den Berg, H. & Bast, A. (2001). Transcription factor NF-κB as a potential biomarker for oxidative stress. British Journal of Nutrition, 86, S121-S127.
  21. Van der zijpp, A. J. & Leenstre, F. R. (1979). Genetic Analysis of the Humoral Immune Response of
  22. 22.    White Leghorn Chicks. Poultry Science, 59, 1363-1369.
  23. Yang, Y., Yuan, Y., Tao, Y. & Wang, W. (2011). Effects of vitamin A deficiency on mucosal immunity and response to intestinal infection in rats. Nutrition, 27, 227-232.
  24. Ying, F. R. Y. (2007). Effects of Zn, Fe and vitamin A interaction on serum antioxidant function in broilers [J]. China Feed, 6, 003.
  25. Yuan, J., Roshdy, A. R., Guo, Y., Wang, Y. & Guo, S. (2014). Effect of dietary vitamin A on reproductive performance and immune response of broiler breeders. PloS one, 9, e105677.
  26. Zaghari, M., Sedaghat, V. & Shivazad, M. (2013). Effect of vitamin E on reproductive performance of heavy broiler breeder hens. The Journal of Applied Poultry Research, 22, 808-813.
Iranian Journal of animal Science
Volume 48, Issue 3 - Serial Number 3
December 2017
Pages 313-319

Files

History

  • Receive Date: 03 January 2017
  • Revise Date: 24 August 2017
  • Accept Date: 25 August 2017

Share

How to cite

Statistics