Meta-Analysis of Genome-Wide Studies to Identify Genetic Networks Underlying Marbling in Beef Cattle

Articles in Press

Document Type : Research Paper

Authors

1 Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Iran.

2 Department of Animal Science, Shahid Bahonar University of Kerman, Kerman, Iran

Abstract

Marbling, or intramuscular fat, is a critical quality trait in beef cattle, directly influencing flavor, juiciness, and tenderness, and significantly contributing to the economic value and marketability of beef. This meta-analysis aimed to identify genomic regions and gene networks associated with marbling in beef cattle. Utilizing data from genome-wide association studies (GWAS) and gene coexpression network analysis, we investigated genomic regions and candidate genes influencing this trait. Data were collected from reputable scientific databases, standardized, and analyzed using Fisher’s and Stouffer’s statistical methods to enhance statistical power. Results revealed that chromosome 15, harboring the CADM1 gene with the highest significance level (-log10(p) = 29.24), plays a pivotal role in regulating marbling. Chromosomes 1, 2, 12, 17, 19, and 24 were also identified as key regions containing genes related to lipid metabolism and immune response. Gene coexpression network analysis identified two hub genes, CLEC12A and CD69, on chromosome 5, which regulate biological pathways including lipid metabolism, immune regulation, cellular signaling, and transcriptional control. The scale-free network structure demonstrated biological stability and flexibility. These findings provide opportunities for developing molecular markers for targeted genomic selection, enhancing beef quality and increasing the global competitiveness of the beef industry. Future studies leveraging whole-genome sequencing and multi-omics analyses can further refine these results.

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Iranian Journal of animal Science

Articles in Press, Accepted Manuscript
Available Online from 26 August 2025

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History

  • Receive Date: 02 July 2025
  • Revise Date: 05 August 2025
  • Accept Date: 08 August 2025

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