Iranian Journal of animal Science

Iranian Journal of animal Science

A comprehensive study of the prevalence of canine parvovirus (CPV-2) in Iran and ‎phylogenetic comparison of dominant Iranian CPV-types with other global types ‎based on VP2 gene ‎

Document Type : Research Paper

Authors
Reza Faraji 1
Ardeshir Nejati Javaremi 2
Mostafa Sadeghi 3
Reza Miraei Ashtiani 2
Hamid Reza Mozhgani 4
1 Ph.D. Candidate in Animal Breeding & Genetics, College of Agriculture & Natural Resource, ‎Unversity of Tehran, Karaj, Iran
2 Professor in Animal Breeding & Genetics, College of Agriculture & Natural Resource, Unversity of Tehran, Karaj, Iran
3 Associate Professor in Animal Breeding & Genetics, College of Agriculture & Natural Resource, Unversity of Tehran, Karaj, Iran
4 Assistant Professor of Virology, Alborz University of Medical Sciences, Karaj, Iran‎
10.22059/ijas.2020.308036.653795
Abstract
Nowadays one of the major challenges facing herders, dog owners, or working dog training centers is canine parvovirus (CPV-2). The virus has split into several types over the years since it discovered and resulted to genetic and amino acid changes that threaten a wide range of carnivorous around the world. The best way to avoiding the consequences of this disease is vaccination. This study were designed, due to the lack of sufficient studies on the distribution and prevalence of different types of this virus, which may be a prominent cause of vaccine errors, also because of high involvement of Iranian dogs with CPV. Molecular study and phylogenetic comparison of Iranian types compared to other types through the world showed that the dominant type of CPV-2 existed in Iran is CPV-2a with a prevalence of 24% and genetic differences in several points of VP2 gene with other types. We are probably facing to a new version of this virus in our country. In addition, based on the drawn phylogenetic tree, it was found that Iranian isolates on the other side have a relatively high topological difference compared to the origin types and conventional vaccines strain, which supports the initial hypothesis of this study.
Keywords
Canine
CPV-2
parvovirus
phylogenetic
VP2 gene‎
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Iranian Journal of animal Science
Volume 52, Issue 1
Spring 2021
Pages 11-21

  • Receive Date 15 August 2020
  • Revise Date 28 September 2020
  • Accept Date 10 October 2020