@article { author = {bahari, ali asghar and ali arabi, hasan and tabatabayi, mohammad mehdi and dezfoolian, amir hossein and rashidi, javad and zamani, pooya and alipor, daryoosh and sadeghi nasab, ali and bakhtiari, zahra and fadayifar, amir}, title = {The influence of different levels and sources of supplemental copper on hematological values, ceruloplasmin and plasma concentrations of copper, zinc and iron in Mehraban male lambs}, journal = {Iranian Journal of animal Science}, volume = {43}, number = {2}, pages = {161-171}, year = {2012}, publisher = {پردیس کشاورزی و منابع طبیعی دانشگاه تهران}, issn = {2008-4773}, eissn = {2423-7949}, doi = {10.22059/ijas.2012.28525}, abstract = {This study was conducted to determine the effects of different levels and sources of copper supplementation on hematological values, ceruloplasmin and plasma copper, zinc and iron status in Mehraban male lambs. Twenty growing lambs were randomly allotted to four different treatments. Treatments consisted of 1) 10 mg/kg Cu in the form of CuSO4, 2) 20 mg/kg Cu in the form of CuSO4, 3) 10 mg/kg Cu in the form of Cu-Proteinate and 4) 20 mg/kg Cu in the form of Cu-Proteinate, administered daily with the basal diet. Blood samples were taken via the jugular vein on days 0, 7, 14, 28, 57 and 65 then analyzed for hematological parameters. The samples taken on days 28 and 65 were also used for a determination of serum ceruloplsmin activity as well as plasma Cu, Zn and Fe concentrations. There was a significant (P < 0.001) negative correlation observed between plasma Cu and Fe (r = -0.604), and as plasma Cu increased (up to d 65) plasma Fe concentrations decreased in all the treatments. Copper source exerted a signi?cant effect on ceruloplasmin concentration (P < 0.05). on d65, the 20ppm Cu-proteinate treatment carried the highest ceruloplasmin concentration (P < 0.05). Copper level exerted a significant effect on RBC, PCV and Hb, with the treatment of 20 ppm level causing higher values (P < 0.05). No clinical or hematological signs of copper toxicity were observed throghout the study. There was an evidence of adverse effects of high Cu supplementation on RBC count, PCV and Hb at the conclusion of the experiment. It can be concluded that the obtained result may be due to Cu interaction with iron as well as its effect on iron metabolism and hematopoesis.}, keywords = {blood hemoglobin,Hamedan.,Hematocrit,Red blood cell count}, title_fa = {اثر سطح و نوع مکمل مس بر فراسنجه‌های هماتولوژی، سرولوپلاسمین و غلظت پلاسمایی مس، روی و آهن در بره های نر مهربان}, abstract_fa = {ین پژوهش برای بررسی اثر سطح و نوع مکمل مس بر فراسنجه های هماتولوژی بره‌های نر مهربان انجام شد. تعداد 20 راس بره نر در قالب چهار گروه پنج راسی در جایگاه‌های انفرادی نگهداری شدند. مقدار و نوع مکمل مس گروه‌های مختلف 10 و 20 میلی گرم در کیلوگرم به شکل سولفات و 10 و 20 میلی گرم در کیلوگرم به شکل ‌پروتئینات بودند که روزانه همراه جیره پایه در اختیار بره‌ها قرار می‌گرفت. در روزهای صفر، 7، 14، 28، 57 و 65 آزمایش بره‌ها از ورید وداج خونگیری شدند و فراسنجه های خونی آن ها تعیین گردید. همچنین از نمونه های روزهای صفر، 28 و 65 برای تعیین میزان مس، روی و آهن پلاسمایی و سرولوپلاسمین سرمی استفاده شد. همبستگی منفی معنی‌داری (001/ 0P}, keywords_fa = {عداد گویچه‌های سرخ,هماتوکریت,همدان.,هموگلوبین خون}, url = {https://ijas.ut.ac.ir/article_28525.html}, eprint = {https://ijas.ut.ac.ir/article_28525_01eecde79c4b83200b5994aa52aafa86.pdf} }